Our publications

• Marin-Cuartas M, Dalbesio B, Pollari F, Scarpanti M, Anselmi A, Cuesta M, Uva MS, Verhoye JP, Musumeci F, Barili F, Parolari A. Five-Year Mortality of Surgical and Transcatheter Aortic Valve Replacement in the Real-World Scenario: A Systematic Review and Meta-Analysis of Propensity Score Matching Studies. Braz J Cardiovasc Surg. 2025 Apr 23;40(4):e20240048. doi: 10.21470/1678-9741-2024-0048. PMID: 40266968; PMCID: PMC12017277.
• Anselmi A, Garcia-Villareal OA, Redberg R; International Evidence Grading Research Initiative Targeting Transparency and Quality (INTEGRITTY). Transcatheter Valve Repair in Heart Failure with Moderate to Severe Mitral Regurgitation. N Engl J Med. 2025 Feb 13;392(7):723-724. doi: 10.1056/NEJMc2416116. PMID: 39938104.
• Ronco D et Al.;Conflicts of interest in clinical practice: lessons learned from cardiovascular medicine. Eur J Cardiothorac Surg. 2024 Sep 2;66(3):ezae296. doi: 10.1093/ejcts/ezae296. PMID: 39313866; PMCID: PMC12017469.
• Anselmi A, Beurtheret S, Barili F, García-Villarreal OA; International Evidence Grading Research Initiative Targeting Transparency and Quality (INTEGRITTY). From information creep to indication creep. J Thorac Cardiovasc Surg. 2024 Mar 15:S0022-5223(24)00108-9. doi: 10.1016/j.jtcvs.2024.02.003. 

• Kaul S, Mancini GBJ, Weintraub WS, De Caterina R; INTEGRITTY. Drawing Conclusions From Exploratory Analyses: A Slippery Slope. J Am Coll Cardiol. 2024 Jan 30;83(4):e31. doi: 10.1016/j.jacc.2023.10.050. 

• Barili F, Anselmi A, Boden WE, Sousa Uva M, Parolari A; International Evidence Grading Research Initiative Targeting Transparency and Quality (INTEGRITTY). Risk of Bias in Randomized Clinical Trials Comparing Transcatheter and Surgical Aortic Valve Replacement: A Systematic Review and Meta-analysis. JAMA Netw Open. 2023 Jan 3;6(1):e2249321. https://doi.org/10.1001/jamanetworkopen.2022.49321

• Abstract 15085: Analysis of the Composite of Death and Stroke at Follow-Up Among Risk Profiles in Trials Comparing Transcatheter and Surgical Aortic Valve Implantation. A Systematic Review and Meta-Analysis (Circulation, Originally Published 6 November 2023) https://doi.org/10.1161/circ.148.suppl_1.15085

• Barili F, Anselmi A, Boden WE, Sousa Uva M, Parolari A; International Evidence Grading Research Initiative Targeting Transparency and Quality (INTEGRITTY). Concerns regarding the report of 3-year outcomes of the Evolut Low Risk trial. J Am Coll Cardiol. 2023 Sep 19;82(12):e101. 

• Parolari A, Almeida RMS, Boden WE; INTEGRITTY (INTernational Evidence Grading Research Initiative Targeting Transparency and data qualitY) group. The sounds of silence. Eur Heart J. 2022 Aug 14;43(31):2997.  https://doi.org/10.1093/eurheartj/ehac333

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Members’ publications related to the initiative

• The new ESC/EACTS recommendations for transcatheter aortic valve implantation go too far https://doi.org/10.1093/eurheartj/ehac154

• Five-year outcomes in trials comparing transcatheter aortic valve implantation versus surgical aortic valve replacement: a pooled meta-analysis of reconstructed time-to-event data https://doi.org/10.1093/ejcts/ezab516

• Myocardial revascularization in ischaemic cardiomyopathy: routine practice vs. scientific evidence https://doi.org/10.1093/eurheartj/ehab680

• Myocardial Revascularization in Patients With Ischemic Cardiomyopathy: For Whom and How https://doi.org/10.1161/JAHA.122.026943

• Lessons Learnt from Recent Trials in Ischemic Heart Disease https://doi.org/10.1055/s-0040-1715830

• The 2021 American College of Cardiology/American Heart Association/Society for Cardiac Angiography and Interventions guideline for coronary artery revascularization. A worldwide call for consistency and logic https://doi.org/10.1016/j.jtcvs.2022.09.032

• Randomized Trials vs Real-world Evidence: How Can Both Inform Decision-making? https://doi.org/10.1001/jama.2023.4855

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Ongoing projects

• Sylvain Beurtheret, et Al. Compound Effect: Misjudging the Lifesaving Role of Surgical Bailout (JACC)
• From the Hazards of Death to the Hazard of Indication Creep for TAVR (JACC)
• Diving into conflicts of interest in cardiovascular research: Analitic review of influences of overt and secondary COIs on cardiovascular RCTs through examples from study design to results reporting and interpretation (spin).
•  Analysis of Variability in Coronary Revascularization Strategy for Stable Multivessel Coronary Disease.  Heart Team-based decision-making is considered in international guidelines a cornerstone in the management of stable, multivessel coronary artery disease. Nonetheless, there can be a substantial variability in practices and decision-making among different modalities of coronary revascularization accross cardiac centers, with potential impact on patients’ outcome. Large Registry analysis including substantial clinical data at follow-up may offer a unique opportunity to investigate such variability and the following patient-outcomes in the real-life.
• Relativity of time in the follow-up of mitral interventions. We commented on a large registry comparing M-TEER (mitral transcatheter edge-to-edge) and mitral surgery, where the duration of follow-up (median: 0.4 years) does not authorize to conclude over ‘long-term’ clinical results; this and other factors, such as the time-variant effect in the relative risk of adverse events and the level of predicted operative risk, need to be carefully considered when interpreting the results of such invetsigations.